NuaDerma

¿What is NuaDerma®? +

NUADERMA® is a food supplement designed to protect the skin from chronological aging and photoaging (‘nutricosmetic’). It is therefore a broad spectrum food supplement, designed to be used all the year round.

Its use is highly recommended in situations of high exposure to environmental factors that are likely to damage more intensively the skin (ie. outdoor sports, sunbathing on beaches and swimming pools etc.) and in people whose skin is specially sensitive to solar radiation (‘light skin’). In addition, it offers an ideal nutritional support in cases where there is some type of skin disorder (ie. atopias, psoriasis, rosacea, irritations, etc.), specially if it is of long duration.

NUADERMA® can be used by people of all ages.

Skin aging +

Cutaneous aging is the sum of chronological aging, or aging derived from the passage of years, and photoaging, which is caused by solar radiation, and will depend on the degree of sun exposure and pigmentation of the skin.Although chrono-aging is “innevitable”, the degree of photoaging depends on our lifestyle and skin care measures, so we can act on it to reduce its effect.

As as far as the solar radiation is concerned:

  • solar radiation is one of the main causes of free radicals production in the skin, responsible for skin aging and the appearance of skin diseases, such as skin cancer.
  • although UVB radiation is the cause of redness and burning of the skin, its damage is limited to the summer months and central hours of the day, while UVA radiation (mainly responsable for wrinkles and skin aging, as well as skin cancer) has the same intensity and the same harmful effect on the skin throughout the year. That is why it is necessary to protect our skin from UVA radiation all the year round.

Photoprotective creams with SPF (SPF 10, FPS30 etc.) protect us against UVB radiation, but not against UVA. In addition, these creams tend to be used mainly in summer months and in many cases inadequately. While there are creams that provide protection against both UVB and UVA, it is necessary for the contribution of the UVA protection to be adequate (the value of protection must be at least 1/3 of the value of protection for UVB).

Why use NuaDerma® +

Various reasons justify taking a nutricosmetic like NuaDERMA:+ it offers the possibility of protecting yourself from sun damage orally (oral photoprotection) throughout the year.

+ it increases the natural resistance of the skin to solar radiation which, in practice, means that it takes longer to ‘turn red’ due to sun exposure (increase in the ‘minimum erythematic dose’ or MED: dose of solar radiation needed to begin to redden the skin). Therefore, although NuaDERMA does not substitute sunscreen creams, it is an ideal complement and, by itself, provides a basic protection to the skin.

+ it allows to improve aesthetic aspects related to sun exposure and the passage of time (ie. dark spots or wrinkles).

+ beyond the protection against solar radiation (UVA and UVB), NuaDERMA’s ingredients counteract part of the harmful action of free radicals on the skin and at the same time, ‘nourish’ the skin from the surface to its deepest layers.

+ its regular use offers protection to the skin, from the inside, throughout the year and in a uniform way.

Main benefits of NuaDerma® +

  • It provides greater resistance to sun exposure throughout the year (it complements, but does not replace sunscreen creams), specially indicated for those with low skin phototype * (light skin) and who therefore need more protection of their skin throughout the year.
  • Protects the skin of people who use tanning beds regularly.
  • Acts against the chronoaging, contributing to strengthen the firmness and elasticity of the skin.
  • Acts against photoaging, derived from the continued exposure to solar radiation. Suitable for people who practice outdoor sports on a continuous basis (hiking, skiing, sailing, …) or who, due to their activity, spend a lot of time outdoors.
  • Increases the natural protection of the skin against factors that contribute to the appearance of skin cancer.

(*) ‘skin phototype’ is a term that refers to the skin color, ranging from very light-pale skin (phototype I) to really dark skin (phototype VI). The lower the phototype the more vulnerable it is to suffer damage from solar radiation (ie. redness and burns).

Format, dosis and use instructions +

Daily recommended dose: 1 capsule per day.The effects of NUADERMA® are not immediate and will require a minimum intake period of 2 months. This is so because skin cells require certain time for their renewal and therefore, to incorporate the nutrients provided by the formulation. The greater the time taking the supplement, the greater the improvements observed.

Use instructions: 1 capsule with a meal. This supplement can be used by people of any age.

Remark: this supplement does not substitute sunscreen creams, although it is a complementary support.
Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Store in a dry and cool place. Keep out of the reach of children.

Composition of NuaDerma® +

INGREDIENT mg/cap %DRD
Hydroxytyrosol 10 -
Nutroxsun® 100 -
Vitamin C (Ester-C®) 180 180
Vitamin E 30 250
Zinc 15 150
Vitamin A 1,2 mcg 150
Copper 1 100
Vitamin D 0,0075 150
Silicon 50
Selenium 0,055 100
Chromium 0,1  250

DRD: Daily Recommended Dose

Main ingredients +

“In order to understand the broad spectrum of uses of NuaDERMA, it is important to understand what each ingredient is capable of doing”.
  • Hydroxytyrosol:

Hydroxytyrosol is a phenol from olives that stands out for being one of the most powerful natural antioxidants known. Very effective against free radicals whihc are specially harmful to the skin (ie. superoxide anion, peroxide and hydroxyl).

  • Nutroxsun®:

Propietary blend formed by rosemary phenols and grapefruit bioflavonoids with proven effects at the skin level, as it increases the Minimum Erythematous Dose (MED), thereby increasing skin protection against UVB damage. Also, through specific studies carried out with this extract, it has been proven that it is able to improve the elasticity of the skin and reduce the depth of wrinkles.
* MED (Minimum Erythematous Dose): dose of solar radiation needed to make the skin red. An increase in MED means that it takes longer for skin to burn (redness) from the sun.

  • Vitamin C (Ester C®):

Vitamin C is water soluble and ester-C is its most bioavailable and bioactive form. Vitamin C is essential to preserve the integrity of collagen, also contributing to slow down its degradation. These explains its contribution to the reduction of wrinkles and increase of the skin firmness and elasticity. It also protects the skin from oxidative damage, being effective against both UVA and UVB radiation.
According to EFSA (European Food Safety Authority), vitamin C contributes to the normal formation of collagen for the normal functioning of the skin.

  • Vitamin E:

Vitamin E deposits are depleted by UV radiation. It works synergistically with vitamin C, enhancing its photoprotective effect. It also offers protection against melanoma.
• Vitamin A (as Betacarotene):
Beta-carotene is the precursor of vitamin A in the body, an important free radical scavenger whihc has a photoprotective effect against photoinduced erythema (or ‘skin redness’, specially in the epidermis). It also contributes to a uniform sun tan.
According to EFSA, vitamin A contributes to the maintenance of the skin under normal conditions.

  • Zinc:

One of the most abundant minerals in the skin, specially in the epidermis. It is involved in skin wound healing as well as in anti-inflammatory processes.

According to EFSA, zinc contributes to the maintenance of the skin under normal conditions.

  • Copper:

An important mineral for the antioxidant defenses of the skin, the formation of collagen and melanin.
According to EFSA, copper contributes to normal skin pigmentation.

Other ingredients of the formulation +

  • Vitamin D3:

UV rays that impact the skin, initiate a process that will eventually convert subcutaneous cholesterol into Vitamin D3 which, among other things, is necessary to enable absorption of calcium from the diet. The application of photoprotective creams will prevent this process, and may cause deficient states of this important vitamin. Likewise, highly pigmented skins produce less vitamin D and, therefore, present deficient states.
On the other hand, vitamin D is important in preventing skin cancer, as it protects cells from UVB-induced cell damage and death, while regulating the proliferation and differentiation of keratinocytes, essential for maintaining the skin barrier function and preventing the uncontrolled growth that leads to cancer. It is also a relevant vitamin in skin immunity. Vitamin D3 is more bioassimilable than D2.

  • Organic silicon:

Cutaneous aging is associated with a loss of silicon. Silicon is necessary for an adequate synthesis of skin collagen and structural molecules of the dermis (ie. proteoglycans). This provides a greater resistance and elasticity to the skin which results in an improvement of skin wrinkles. The effects of this mineral are also evident in the quality of hair and nails. In NuaDERMA, the organic silicon comes from natural bambu extract.

  • Chromium:

Over the years, sugar molecules from the diet often bind to body proteins such as collagen in the skin, resulting in the formation of substances known as AGE’s (‘advanced glycosylated products’), which can alter the structure and function of these proteins. Glycosylation also affects the elasticity of the skin. Chronic skin aging is associated with an increase in AGE’s, and therefore, chromium’s purpose is to contain this process (thanks to its ability to lower sugar levels), an effect that is supported by vitamin C. Note: given its benefits, chromium can reduce blood glucose levels.

Bibliography +

  • Bickers DR & Athar M (2006) Oxidative Stress in the Pathogenesis of Skin Disease. J Investigative Dermatology 126: 2565-2575
  • Bickle DD (2011) Vitamin D metabolism and function in skin. Mol Cell Endocrinol 347 (1-2): 80-89
  • D’Angelo et al., (2005) Hydroxytyrosol, a natural antioxidant from olive oil, prevents protein damage induced by long-wave ultraviolet radiation in melanoma cells. Free Radic Biol Med. 2005 Apr 1;38(7):908-19.
  • Gkogkolou P & Böhm M (2012) Advanced glycation end products: Key players in skin aging?. Derma-Endocrinology 4:3, 259-270
  • Kumar P et al., (2012) Zinc and skin: A brief summary. Dermatology online Journal, March 2012: 4 pages
  • Kulka M (2013) Mechanisms and Treatment of Photoaging and Photodamage. In: Using Old Solutions to New problems-Natural Drug Discovery in the 21st Century (Ed. InTechOpen), (Chapter 9)
  • Marmett B & Barcos Nunes R (2016) Effects of Chromium picolinate supplementation on control of metabolic variables: a systematic review. J Food & Nutrition Research 4(10): 633-639
  • Nobile V et al., (2016) Skin photoprotective and antiageing effects of a combination of rosemary (Rosmarismus officinalis) and grapefruit (Citrus paradisi) polyphenols. Food & Nutrition Research 60: 3I87I, 15 pages.
  • Pérez-Sánchez A et al., (2014) Protective effect of citrus and rosemary extracts on UV-induced damage in skin cell model and human volunteers. J Photochemistry & Photobiology B 136 (20): 12-18
  • Quan T et al., (2009) Matrix-degrading metalloproteinases in Photoageing. J Investig Dermatol Symp Proc 14(1): 20-24
  • Rinnerthaler M et al., (2015) Oxidative stress in aging human skin. Biomolecules 5: 545-589
  • Saewan N & Jimtaisong A (2013) Photoprotection of natural flavonoids. J Applied Pharmaceutical Science 3(09): 129-141
  • Schagen SK et al., (2012) Discovering the link between nutrition and skin aging. Dermato-Endocrinology 4;3, 298-307